What we do
Stimuliver safely supplements the liver’s functioning through a remote implant, which helps filter toxins and take the burden off the liver.
It’s a radically different approach, which bypasses the need for donor tissue, with a ready-made, automated, scalable design.
Main benefits
Renewable
Pluripotent stem cells cultured independently from the donor organs provide a renewable source of liver tissue
Off-the-shelf
Our implants are produced through a scalable, automated process providing clinics with a ready-made product.
Remote
Regeneration
Subcutaneous implants control cell disposition, bypassing abdominal inflammation in liver patients for improved effectiveness.
Stimuliver's implant breakthrough
Stimuliver introduces a novel approach to liver supplementation with its remote implant technology. This innovative solution enhances liver function by filtering toxins and alleviating the organ's workload, eliminating the need for donor tissue. At its core, the implant integrates with the liver, acting as a dedicated assistant in detoxification processes. This scalable and automated design offers a ready-made alternative to traditional transplantation, reducing dependency on limited donor organs and providing hope for those with liver impairments.
How it works
1. Differentiation
Human pluripotent stem cells are differentiated into hepatic progenitors and endothelial cells.
2. Production
Differentiated cells are combined into spheres and scaled up through an automated procedure to create liver tissue.
3. Implantation
Liver tissue loaded scaffolds are implanted beneath the patient’s skin to begin filtering the toxins out of the body.
Publications
28 October 2020, Biofabrication 13 (2021) 015009
Development of a cost-effective automated platform to produce human liver spheroids for basic and applied research
B Lucendo-Villarin, J Meseguer-Ripolles, J Drew, L Fischer, E Ma, O Flint, K J Simpson, L M Machesky, J C Mountford and D C Hay
18 June, 2021, STAR Protocols 2, 100502
Protocol for automated production of human stem cell derived liver spheres
Jose Meseguer-Ripolles, Alvile Kasarinaite, Baltasar Lucendo-Villarin, David C. Hay
28 August 2018 Archives of Toxicology (2018) 92:3117–3129
3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo
Hassan Rashidi, Nguyet‑Thin Luu, Salamah M. Alwahsh1, Maaria Ginai4, Sharmin Alhaque1, Hua Dong, Rute A. Tomaz, Bertrand Vernay. Vasanthy Vigneswara, John M. Hallett, Anil Chandrashekran, Anil Dhawan, Ludovic Vallier, Mark Bradley, Anthony Callanan, Stuart J. Forbes, Philip N. Newsome, David C. Hay
